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4.įor example, both CD4 + CD25 + and CD4 + CD25 − T cells from tolerant mice could mediate suppression, although CD4 + CD25 + T cells were more efficient than CD4 + CD25 − T cells 8. Nonetheless, peripheral mature CD4 + CD25 − T cells can also be induced to acquire inhibitory function in vivo 2. CD25 has been used as a traditional, albeit imperfect, marker for CD4 + Foxp3 + Tregs. Naturally-occurring CD4 + Foxp3 + cells are considered to be one of the main types of T regulatory cells (Tregs), which are involved in regulating a wide range of activities including the responses to autoantigens, alloantigens, tumor antigens, pathogen-derived antigens, and even the maintenance of normal pregnancy 1. Regulation is central to immune responses and immune tolerance. NK cells T cells suppression melanoma metastasis Qa-1. Activated mouse CD4 + Foxp3 − T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity.
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